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CARDIO-TTRansform

A clinician performs an echocardiogram, an ultrasound scan of the heart, on a patient

What it really means when a clinical trial fails its main goal

A missed primary endpoint is still evidence. Using the 2026 CARDIO-TTRansform trial, this guide explains neutral results, subgroups, safety and what happens next for patients.

23 October 2026

DPD bone-tracer scintigraphy scan showing tracer uptake in the heart caused by transthyretin amyloid deposits

Cardiology

Monthly gene-silencing jab fails to cut events in stiff hearts

In the CARDIO-TTRansform trial, monthly eplontersen lowered the faulty TTR protein but did not significantly reduce heart deaths and events in amyloid cardiomyopathy over 140 weeks.

28 August 2026